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09:30 - 09:45
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Paper No. 2014-FRI-S0603-O002
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| Yong Da Sie
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Fabrication of Multi-Layer 3D Biopolymer Microstructures via Multiphoton Excited Photochemistry
Yong Da Sie,Nan-Shan Chang,Shean-Jen Chen,
To fabricate complex 3D structure with nature proteins and overcome the nature limitation of fibronectin (FN) stacking in 3D conditions, bovine serum albumin (BSA) protein can easily form complex 3D scaffold via multiphoton excited photochemistry, then FN can be fabricated at specific location on BSA scaffold to help and guide cell growing three-dimensionally
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09:45 - 10:00
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Paper No. 2014-FRI-S0603-O009
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| Jia-Wen Hsu
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Zebrafish models of ischemic and hemorrhagic stroke induced with photochemical thrombosis and ablation
Jia-Wen Hsu,I-Ju Lee,Yen-Ling Chen,Ian Liau,
We developed two laser based methods – photochemical thrombosis and femtosecond laser ablation – to induce ischemic and hemorrhagic stroke at selected cerebral blood vessels of zebrafish larvae. Our novel zebrafish models of stroke combined with fluorescent imaging facilitate visualization of neovascularization and rerouting of cerebral vessels after stroke.
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10:00 - 10:15
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Paper No. 2014-FRI-S0603-O012
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| Lan-lin Jang
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Optical Measurement on Cell Membrane Roughness Influenced by Paclitaxel and Gold Nanoparticles
Lan-lin Jang,
We measured the membrane roughness of
neuroblastoma cells under the treatments of gold
nanoparticles (AuNPs) and paclitaxel. The positive charges
on AuNPs reduced the roughness of cell membranes. The
stabilization of intracellular microtubules by paclitaxel led
to similar results.
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10:15 - 10:30
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Paper No. 2014-FRI-S0603-O021
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| Zhung-Fu Lee
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Using optical coherence tomography to investigate temporal effects induced by microneedle for transdermal drug delivery
Zhung-Fu Lee,Ting-Yen Tsai,Feng-Yu Chang,I-Chi Lee,Chih-Hsun Yang,Meng-Tsan Tsai,
Transdermal drug delivery systems (TDDS) have been an attracting field in drug delivery because of its benefit over parenteral and oral administration. Recent studies illustrate that microneedle (MN) can penetrate through stratum corneum (SC) barrier without damaging nerves. In this study, we used optical coherence tomography (OCT) to investigate the temporal effects on skin induced by MN for transdermal drug delivery. With OCT, the morphological changes in skin due to MN can be identified from 2D or 3D OCT image. Moreover, the penetration depth and damaged area can be quantitatively evaluated. In addition, OCT was used to reconstruct micro-angiography of mouse skin and to observe the changes in micro-angiography induced by MN. Finally, OCT is implemented for dynamic evaluation of skin recovery after using MN array for drug delivery.
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10:30 - 10:45
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Paper No. 2014-FRI-S0603-O024
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| Szu Yu Lee
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Submicron Photoacoustic Microscopy with High Imaging Rate
Szu Yu Lee,Chi Kuang Sun,
Conventional Photoacoustic microscopy (PAM) enhances ultrasonically determined resolution at the expense of penetration depth. Also, high resolution PAM usually uses time consuming mechanical scanning, which lacks of practicality. In this paper, we propose a high frame rate laser scanning PAM, which features an optically determined submicron resolution.
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10:45 - 11:00
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Paper No. 2014-FRI-S0603-O033
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| Ryosuke Oketani
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Modification of Point-Spread Function in Confocal Imaging by Using Nonlinear Light Scattering
Ryosuke Oketani,Hsueh-Yu Wu,Hsuan Lee,Yen-Ta Huang,Yasuo Yonemaru,Tung-Yu Su,Satoshi Kawata,Shi-Wei Chu,Katsumasa Fujita,
We experimentally observed the change of imaging property of confocal microscopy during observation of a gold nanoparticle with different illumination intensities. Modification of the point-spread function through the nonlinear nature of plasmonic scattering, which has been reported previously, was confirmed. We extracted the nonlinear scattering components for high spatial-resolution imaging.
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