Formation of perfusable vascular networks is an important topic for tissue engineering. We cocultured human umbilical vein endothelial cells with hepatocellular carcinoma cells as spheroids of various sizes, and used selective plane illumination and confocal microscopy to monitor the structures of the endothelial cells inside a spheroid.

 Preview abstract

The fabrication of Ce-doped fibers (CeDFs) employing drawing-tower method with rod-in-tube and powder-in-tube technique is demonstrated. The fluorescence spectrum of CeDFs exhibited a 120-nm broadband emission with 1.45 μm axial resolution. This CeDF may be functioned as a high- resolution light source for optical coherence tomography (OCT) applications.

 Preview abstract

A THz near-field transmission type imaging system is proposed and demonstrated to investigate the blood absorption coefficient in-vivo. The in-vivo absorption coefficient of the blood of nude mouse is successfully found to be around 140cm-1 at 340GHz.

 Preview abstract

Platelets adhering to circulating tumor cells may play an import role in cancer metastasis. In this study, we reveal that platelets adhesion increases cell viscoelasticity and enhance resistance to cellular damage caused by fluid shear stress, resulting in less apoptotic cells and higher metastasis ability.

 Preview abstract

Nonlinear fiber optics and nonlinear light microscopy are two totally distinct research areas. In this work, we demonstrate that by efficient wavelength-conversion mechanisms in a highly nonlinear fibers. And the fiber-delivered femtosecond 1.2-1.35 micron down-converted and 0.6-0.8 micron up-converted light sources were then utilized for nonlinear microscopy for the first time.

 Preview abstract

We submitted the design of an IR microbolometer to Chip Implementation Center (CIC) in Taiwan. After we received the chips back from CIC, we ink-jetted Cytochrome c protein onto the aluminum electrode. Finally, we demonstrated the TCR of 28.27%. This value is much higher than most materials used in microbolometers.

 Preview abstract

In this paper, we proposed a three-layer structure Au/ITO/Au fiber sensor based on surface plasmon resonance to improve the sensing sensitivity for the index-matching oil measurements with the refractive index ranged from 1.30 to 1.39. The results show the sensitivity can be increased 25.8% significantly.

 Preview abstract

In light of the limitation of conventional animal models of thrombosis, we develop an application of a photochemical means to initiate thrombosis in targeted blood vessels of zebrafish larvae. This approach is extensible to induce ischemic stroke in zebrafish and may facilitate the screening of drugs with thrombolytic capability.

 Preview abstract

We propose a new optical fiber sensor with bi-metal layers structure based on surface plasmon resonance to study the sensing sensitivity improvement under an applied external magnetic field. The results show that the magnetic field can enhance the sensing sensitivity and change the resonance absorption dip wavelength obviously.

 Preview abstract

We numerically investigate a periodic array of silver-shell nanorod pair structure by using finite element method. Simulation results show that the SPR modes are very sensitive to the relative permittivities change in the surrounding materials, which could be used as highly sensitive sensors.

 Preview abstract

Recognizing different types of leukocytes without a label is very helpful for flow cytometry in clinical medicine. Here we show a new method to differentiate the types of human leukocyte by using third harmonic generation and two-photon auto-fluorescence microscopy. Cell identities were confirmed by immunohistochemical fluorescence labels.

 Preview abstract

In this study, the spectrum of each picture element of the patient’s skin image was obtained by multi-spectral imaging technology (MSI). Spectra of normal or pathological skin were collected from 30 patients (10 early stage MF, 10 psoriasis vulgaris, and 10 atopic dermatitis). An algorithm combined with multi-spectral imaging and color reproduction technique is applied to find the best enhancement of the difference between normal and abnormal skin regions. Accordingly, an illuminant with specific intensity ratio of red, green, and blue LEDs is proposed, which has optimal color enhancement for MF detection. Compared with the fluorescent lighting commonly in the use now, the color difference between normal and inflamed skin can be improved from 11.8414 to 17.4002 with a 47% increase, 8.7671 to 12.8544 with a 26.3% increase, and 11.0735 to 17.2634 with a 34.3% increase for MF, psoriasis, and atopic dermatitis patients, respectively, thus making medical diagnosis more efficient, so helping patients receive early treatment.

 Preview abstract

The first,to our knowledge,very low glucose sensing limit(0.01mg/dL) after immobilized glucose oxidase technique was demonstrated from our surface plasmon resonator sensing with high telecommunication wavelengthresolution. Its sensitivity was showing 1.56 nm/(mg/dL).

 Preview abstract

In order to whether psoralen plus UVA (PUVA) could help photochemotherapy, the transmittance and Raman spectra will be done for the detection. The results exhibited the psoralen plus UVA LED lighting source could add the transmittance and the reaction peaks in the Raman spectra.

 Preview abstract

We combine surface plasmon resonance and electrochemical techniques to regulate the oxygen-containing functional groups of graphene oxide, and thus induced band gap to enhanced surface plasmon coupling effect.

 Preview abstract